Importance of Weight Loss Maintenance and Risk Prediction in the Prevention of Type 2 Diabetes: Analysis of European Diabetes Prevention Study RCT (original) (raw)

“…It is now time to move away from the Sisyphean task of pursuing weight loss aims alone and onto achieving other valued health goals [31]. Lifestyle intervention may reduce type 2 diabetes and cardiometabolic risk by 58%, despite moderate weight loss [32]. Many NCDs have common etiologies, whereby a shift from a vertical to a horizontal approach will ultimately pave the path to more effective prevention and management strategies.…”

Section: Strategy and Perspectivesmentioning

“…Improvements in body weight, diet and exercise capacity can easily be achieved with modest efforts 14. However, more intensive lifestyle interventions and, in particular, a weight loss of at least 5% maintained over a longer period of time had a more pronounced effect in European clinical trials 15,16. Consequently, such improvements were associated with a markedly reduced incidence of diabetes over an observational period of one to several years 15–18, with lifestyle interventions being clearly superior to metformin and also improving associated cardiovascular risk factors such as hypertension and dyslipidaemia 17.…”

Section: Discussionmentioning

“…Data on the timing of the delivery of the protocol were available for 6 out of 10 clubs, either coach-reported or from researcher observation field notes, and five out of six clubs delivered the information on data transfer and linkage during session 6, as per protocol. The total number of men who completed data linkage permission forms across the 10 clubs was 87 (range [5][6][7][8][9][10][11][12][13][14][15][16][17] The number of completed data linkage permission forms returned in phase 2b (range 4-17) was smaller than in phase 1 (range 9-35) and phase 2a (range [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], which may reflect the fact that the data linkage permission process was conducted over two sessions. This conclusion is supported by variation in the dates on the completed data linkage permission forms in some clubs, suggesting that coaches may have had some problems in getting men to complete their forms after session 6 (i.e.…”

Section: Phase 2bmentioning

“…[7][8][9][10] Participants in weight loss programmes typically regain 30-35% of lost weight in the first year post intervention, and most return to their baseline weight within 3-5 years. [11][12][13][14] As long-term weight maintenance is essential to maximise the health benefits associated with weight reduction, 15 it is important to understand how to support people to sustain their weight loss following behavioural interventions. Systematic reviews indicate that a combination of energy and fat reduction, regular PA and behavioural strategies (such as regular weighing) is required for successful long-term weight loss.…”

Section: Chapter 1 Introductionmentioning