Bone Marrow Cell Recruitment to the Brain in the Absence of Irradiation or Parabiosis Bias (original) (raw)

“…In conclusion, BM-derived microglia can engraft into the diseased brain and become an integral part of the cellular network in the CNS only under specific nonphysiological conditions. These specific conditions include irradiation and chemotherapeutic regimes, for example, the application of myeloablating agents, which all (1) alter the integrity of the BBB, and (2) induce local production of myeloattracting chemokines, such as CCL2 (Boettcher et al 2008;Lampron et al 2012;Kierdorf et al 2013b). Taken together, these data also clearly indicate that BM-derived nonmonocytic cells are able to permanently engraft to the diseased brain, whereas shortlived monocytes are only transiently recruited to the CNS.…”