Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders (original) (raw)

“…These deficits of neurotransmitter systems lead to impaired communication between brain regions and eventually behavior disruptions at later stages (Penzes et al, 2013;van Spronsen and Hoogenraad, 2010). For example, in Alzheimer's disease (AD) it was reported that the toxic effects of amyloid pathology and inflammation induce synaptic defects in the cortex and hippocampus, eventually leading to cognitive dysfunctions (Spires-Jones and Knafo, 2012).…”

Section: Introductionmentioning

“…These deficits of neurotransmitter systems lead to impaired communication between brain regions and eventually behavior disruptions at later stages (Penzes et al, 2013;van Spronsen and Hoogenraad, 2010). For example, in Alzheimer's disease (AD) it was reported that the toxic effects of amyloid pathology and inflammation induce synaptic defects in the cortex and hippocampus, eventually leading to cognitive dysfunctions (Spires-Jones and Knafo, 2012).…”

Section: Introductionmentioning

“…[6 ] for a review) -or under disease conditions (reviewed by Penzes at al. [7 ]). In the following section we briefly discuss recent work in which superresolution microscopy has been used to address an important topic in the Neurosciences or played a key role in the experimental approach.…”

Section: Introductionmentioning

“…Evidence from both human genetic and animal model studies suggests that disruption of synaptogenesis is an important component of ASD [32][33][34]. Then, we investigated the effects of prenatal H DAC inhibition on mRNA levels of synaptogenesis-related proteins.…”

Section: Effect Of Nlgn1 Knockdown On Maturation Of Primary Corticalmentioning