Meta‐analysis of insulin aspart versus regular human insulin used in a basal–bolus regimen for the treatment of diabetes mellitus (在基础—餐时糖尿病治疗方案中使用门冬胰岛素与使用常规人胰岛素对照研究的Meta分析) (original) (raw)

“…Consistent with our results for T1DM, the authors also demonstrated a lower risk of nocturnal hypoglycemia in the IAsp group; however, the overall proportion of patients experiencing hypoglycemic episodes was comparable in both arms. The high consistency of our results in T1DM and those presented by Heller et al 40 is of interest as the methodologies of both reports varied substantially. First, the other meta-analysis included solely trials with available IPD, of which some have not been published yet.…”

Section: Discussionsupporting

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“…Consistent with our results for T1DM, the authors also demonstrated a lower risk of nocturnal hypoglycemia in the IAsp group; however, the overall proportion of patients experiencing hypoglycemic episodes was comparable in both arms. The high consistency of our results in T1DM and those presented by Heller et al 40 is of interest as the methodologies of both reports varied substantially. First, the other meta-analysis included solely trials with available IPD, of which some have not been published yet.…”

Section: Discussionsupporting

“…Although a meta-analysis by Heller et al 40 was based on specific information, which could not be easily assessed, it provided valuable complementary and supportive data to our work. Two milestone prospective diabetes studies, The UK Prospective Diabetes Study (UKPDS) and Diabetes Control and Complications Trial (DCCT), demonstrated that more intensive therapies, although improving glycemic control, are almost inevitably associated with an increased risk of severe hypoglycemia.…”

Section: Discussionmentioning

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“…With significant additions to the prandial insulin dose, particularly with the evening meal, consideration should be given to decreasing the basal insulin dose. Meta-analyses of trials comparing rapid-acting insulin analogs with human regular insulin in patients with type 2 diabetes have not reported important differences in A1C or hypoglycemia (78,79).…”

Section: Prandial Insulinmentioning

“…(19) In this study we recorded a higher number of calibration . We will discuss the possible (22) m e c h a n i s m s w h i c h m a y ex p l a i n t h e association between the type of basal insulin and the hypoglycemic events. The impact of rapid human insulin on the risk for nocturnal hypoglycemia was demonstrated and in (22) this analysis the percentage of patients with T1D treated with insulin glargine U100 is higher than of those treated with insulin detemir.…”

Section: Original Papersmentioning