Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence (original) (raw)

“…CCAT1 is markedly overexpressed in CRC 84 and is also upregulated in precancerous tissues, including benign inflammatory colonic tissues and adenomatous polyps. 85 CCAT1 can be detected in CRC tissue and in the blood and stool samples of CRC patients. 86 Thus a CCAT1-based blood/stool assay may be explored for the screening and early detection of CRC.…”

Section: Tumor Diagnosismentioning

“…3,4 Colon cancer-associated transcript 1 (CCAT1), a ~2-kb lncRNA located at chromosome 8q24.21, is first found to be upregulated in colon cancer. 5 Recently, some reports have found that CCAT1 is involved in tumor progression and tumorigenesis in various types of cancers including colon cancer, 6 gastric cancer, 7 and colorectal cancer. 8 The competitive endogenous RNA (ceRNA) mechanism for CCAT1 and microRNAs involving in tumor progression has been reported in some studies, for example, Zhou et al 9 reported the lncRNA CCAT1/miR-490 axis regulated gastric cancer cell migration by targeting hnRNPA1.…”

Section: Introductionmentioning

“…Recently, aberrantly expressed lncRNAs have been found related with CRC. As examples, lncRNAs such as CCAT1 [24][25], CCAT2 [26], HOTAIR [27] and MALAT1 [28] are increased in CRC tissues compared to NATs and have been identified as oncogenes. The lncRNAs can regulate the expression of their target genes, activate some signaling pathways, and promote cell proliferation, metastasis, and tumor recurrence [29][30][31][32].…”

Section: Discussionmentioning