Signals from the lysosome: a control centre for cellular clearance and energy metabolism (original) (raw)

“…As such, impairment of lysosomal function can manifest in diseased states including cancer, lysosomal storage disorders, and neurodegenerative diseases. [5][6][7][8][9] Lysosome function is also required for various other cellular processes including cholesterol homeostasis, plasma membrane repair, antigen presentation, exosome release, and cell migration. 10 Members of Rab, Arf and Arf-like (Arl) GTPases of the Ras superfamily are key molecular players that associate with distinct intracellular organelles and regulate membrane trafficking to and from these compartments.…”