Dietary supplementation with purified mulberry (Morus australis Poir) anthocyanins suppresses body weight gain in high-fat diet fed C57BL/6 mice (original) (raw)

“…The present study showed that Cy-3-g significantly decreased serum TC and LDL-C levels in mice fed high-fat diets. The observed effects of the anthocyanin Cy-3-g in modulating lipid profiles were consistent with previous findings (28).…”

Section: Discussionsupporting

“…High cholesterol levels can increase platelet sensitivity and enhance reactive oxygen species (ROS) formation in the platelet membrane, which increases platelet aggregation and is responsible for the role of platelets in CVDs (26,27). Several studies have indicated that dietary anthocyanins exert an anti-thrombotic effect by regulating TG synthesis or lipid hydrolysis (28,29). The present study showed that Cy-3-g significantly decreased serum TC and LDL-C levels in mice fed high-fat diets.…”

Section: Discussionmentioning

“…The supplementation of C. nutans reduced the size of the abdominal fat cell in mice. Similar to this study, Wu et al [39] concluded that dietary mulberry anthocyanins (MACN) had an effect on both number and the size of adipocytes in mice adipose tissue [40]. The reduction in the size of the abdominal fat cell could be attributed to the bioactivities of the polyphenolic compounds in C. nutans [19,26].…”

Section: Discussionsupporting

“…27 AT2R-KO mice fed a control diet showed a decrease in plasma leptin levels, which may be correlated with the decrease in plasma insulin levels. 28 On the other hand, HFHF-STZ increased leptin secretion, as found by others, 29 in both WT and AT2R-KO mice. The decreased secretion of insulin in AT2R-KO mice fed a control or a HFHF diet could be due to the deleterious action of the AT1R on b-cell survival and insulin biosynthesis and secretion.…”

Section: Discussionsupporting