Integrated Transcriptomic and Epigenomic Analysis of Primary Human Lung Epithelial Cell Differentiation (original) (raw)

“…These lung T RM niches are the tissue repair-associated regions and co-localize with the production of T RM promoting factors TGF-β and IL-15. 47,72 Notably, the regeneration of damaged airway epithelium is also TGF-β-dependent, 78 providing an example of complex functions of TGF-β signaling in both local immunity and tissue homeostasis. The gradual decline of lung T RM cells is caused by the completion of injured lung regeneration and the shrinking of lung T RM niches.…”

Section: Tissue Specific Features Of Trm Cellsmentioning

“…These lung T RM niches are the tissue repair-associated regions and co-localize with the production of T RM promoting factors TGF-β and IL-15. 47,72 Notably, the regeneration of damaged airway epithelium is also TGF-β-dependent, 78 providing an example of complex functions of TGF-β signaling in both local immunity and tissue homeostasis. The gradual decline of lung T RM cells is caused by the completion of injured lung regeneration and the shrinking of lung T RM niches.…”

Section: Tissue Specific Features Of Trm Cellsmentioning

“…Paraffin-embedded normal human lungs were prepared from rejected lung transplant donors (13). This study was approved by the Institutional Review Board for Human Subjects Research and the Institutional Animal Care and Use Committee of the University of Southern California.…”

Section: Processing Of Lung Tissuementioning

“…Analysis of gene expression in human AEC transdifferentiation was recently described (16). Whole lung gene expression analysis of wild-type (WT) versus C18 KO mice was performed using the Illumina MouseRef8 v2 platform (Illumina, San Diego, CA).…”

Section: Microarray Analysis Of Human and Mouse Gene Expressionmentioning