Direct uptake and degradation of DNA by lysosomes (original) (raw)

“…Both CMA and macroautophagy will be discussed in detail later. LAMP-2C is less characterized but is thought to be primarily, and potentially solely, involved in the degradation of RNA and DNA (RNautophagy and DNautophagy, respectively) based on pull-down assays identifying interacting proteins as being RNA-or DNA-binding proteins (Fujiwara et al, 2013(Fujiwara et al, , 2014. Owing to these differences in function and tissue expression, which will be explored more in the following sections, LAMP-2A and LAMP-2B are thought to be more relevant to Danon disease and, consequently, these isoforms will receive more attention than LAMP-2C in this Commentary.…”