Andirolides Q–V from the flower of andiroba (Carapa guianensis, Meliaceae) (original) (raw)

“…Many studies have reported the pharmacological properties of products obtained from the andiroba flower [1,2] , from the ethanolic extract of the andiroba leaf [3,4] and especially products derived from andiroba seed oil [5][6][7] . Andiroba oil is widely used in popular medicine in the Amazon basin region.…”

Section: Introductionmentioning

“…In contrast, compound 2 did not affect cancer cell growth at levels below 100 µM. This latter result corroborates previous publications reporting no cytotoxic effect of 2 toward CHAGO (lung carcinoma), SW-620 (gastric carcinoma), KATO-3 (colon carcinoma), BT-474 (breast carcinoma), and Hep-G2 (hepatocarcinoma) [36], but contrasts with the cytotoxic effect previously noted for mexicanoide-type limonoids: cipadesin N showed moderate cytotoxicity in leukaemia cell lines HL-60 with an IC 50 value of 20 µM [37] and andirolide T showed strong activity in the murine leukaemia cell line P-388 (1.8 µM) and the human leukaemia cell line HL-60 (1.3 µM) [38]. Compound 1 has not previously been studied for its cytotoxic effects.…”

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“…However, other mexicanolide-type limonoids showed some cytotoxic activity due to the presence of other functions that are different from those described above. Indeed, Sakamoto et al found that a 2-methylbutyryloxy group influenced the cytotoxicity of mexicanolide-type limonoids [38]. This was also observed for gedunin type limonoids [37].…”

mentioning

“…Cytotoxic activity of gedunin, from A. indica seed extract, was evaluated against human leukemia cell line HL60, and an IC 50 value of 5.9 µM was observed [32,33]. Sakamoto et al [43] using gedunin extracted from Carapa guianensis Aubl. flower oil, assessed its cytotoxicity against murine P388 leukaemia and HL60 cell lines, and obtained IC 50 values of 16 and 15.2 mM, respectively.…”

Section: Leukemiamentioning