Mendelian Randomization Analysis of the Effect of Maternal Homocysteine During Pregnancy, as Represented by Maternal MTHFR C677T Genotype, on Birth Weight (original) (raw)

“…Yajnik and colleagues (2014), in a study of two independent cohorts from India showed that increase in maternal homocysteine concentration resulted in a small decrease in birth weight and established a causal role for maternal homocysteine in fetal growth. A similar analysis by lee et al from Korea also showed a negative association between maternal homocysteine levels and birth weight; however the association did not reach statistically significant level (Lee et al 2013). Taken together these studies show that elevated total homocysteine concentrations in the mother appear to have a small but significant effect on fetal growth and birth weight.…”

Section: One Carbon Metabolism and The Health Of The Mother Fetusmentioning

“…By 2016, the follow-up of children aged 9 years had been completed. The methodology of the cohort study has been reported elsewhere [ 20 , 21 ]. In this study, two SNPs were genotyped in the subjects who were followed up at least once.…”

Section: Methodsmentioning

“…These metabolic changes often resemble obesity; like metabolic syndrome with increased blood glucose levels [ 3 ]. Developmental programming during pregnancy is affected by metabolic exposures induced by genetic variants, behavioural features and environmental factors [ 4 ]. We have earlier demonstrated that during pregnancy there is profound change in microbial composition from first trimester to third trimester, with an increase in Proteobacteria and Actinobacteria [ 5 ].…”

Section: Introductionmentioning