Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study (original) (raw)

“…The association with hippocampal atrophy appears to be independent of amyloid pathology [14]. White matter lesions reflect vascular damage [92] and it is therefore notable that white matter changes are associated with HHCy [47,49,64,94] and with low vitamin B 12 levels [21] and low folate [51,100]. Evidence supporting a causal relationship between HHCy and cerebrovascular injury includes: i) independent, graded association of HHCy with stroke in prospective and retrospective clinical studies [48,61]; ii) genetic association studies of genes regulating HCy metabolism, using Mendelian randomisation [9]; iii) HHCy-induced lesions in experimental animals [4,68,108,111].…”