Increased longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells (original) (raw)

“…In aged flies, excessive proliferation of intestinal stem cells and the accumulation of mis-differentiated cells in the intestinal epithelium result in intestinal dysplasia (Biteau et al, 2008; Choi et al, 2008; Park et al, 2009), which limits organismal lifespan (Biteau et al, 2010; Hur et al, 2013; Rera et al, 2011; Wang et al, 2014). Previous studies have reported increased microbial loads in aged Drosophila populations (Broderick et al, 2014; Buchon et al, 2009; Guo et al, 2014; Ren et al, 2007) and that flies maintained axenically throughout life display reduced levels of dysplasia and other cellular markers of intestinal aging (Broderick et al, 2014; Buchon et al, 2009; Guo et al, 2014).…”