Role of an excitatory preoptic-raphé pathway in febrile vasoconstriction of the rat's tail (original) (raw)

“…Consistent with this model, L- glutamate injections into the POA, electrical stimulation of the POA and preoptic warming each elicit vasodilation in the rat paw and the rat tail (Zhang et al, 1995). Injection of PGE 2 or GABA into the POA increases CVC SNA (Tanaka et al, 2005; Rathner et al, 2008; Tanaka et al, 2009; Tanaka et al, 2013). Transection of the neuraxis immediately caudal to the POA increases CVC outflow (Rathner et al, 2008).…”

Section: The Hypothalamus In Body Temperature Regulationmentioning

“…Transection of the neuraxis immediately caudal to the POA increases CVC outflow (Rathner et al, 2008). The MnPO contains cold-activated neurons that project to the rRPa and inhibition of neuronal discharge in the MnPO inhibits cold-and PGE 2 -activated increases in CVC (Tanaka et al, 2011; Tanaka et al, 2013). Following the increase in CVC SNA after transection of the neuraxis immediately caudal to the POA, subsequent brain transections caudal to the DMH, but rostral to the rRPa, do not significantly reduce CVC outflow and injection of muscimol into DMH does not affect either spontaneous, thermally-sensitive, CVC neuronal discharge, or that evoked by injection of PGE 2 into the POA (Rathner et al, 2008).…”

Section: The Hypothalamus In Body Temperature Regulationmentioning