Association of Adipose Tissue and Liver Fibrosis With Tissue Stiffness in Morbid Obesity: Links With Diabetes and BMI Loss After Gastric Bypass (original) (raw)

“…The elevated concentrations of FFA reduce the degradation of apolipoprotein B and insulin, which may contribute to the development of the dyslipidemia, hyperinsulinemia, and insulin resistance observed in visceral obesity (178,262,328). Interestingly, both adipose tissue stiffness and elevated serum FFA are associated with markers of hepatocellular damage as well as with liver steatosis and fibrosis (1). On the other hand, obese patients show a decrease in glycerol permeability as well as lower expression of hepatic AQP9, the glycerol channel that mediates glycerol influx into hepatocytes, which suggests an attempt to prevent a further accumulation of TG within the liver parenchyma (266).…”

Section: Recruitment Of Proinflammatory Immune Cells In Obesity Perpementioning