Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (original) (raw)

“…The colon is increasingly recognized for its milieu of bacteria, fungi, protozoa and archaea and rich metabolic activity equated to that of the human liver (Nardone & Malfertheiner, 2011;O'Hara & Shanahan, 2006;Olszewska & Jagusztyn-Krynicka, 2012;Turnbaugh et al, 2007). Recent studies of the human colon microbiome have established various links between nutrition, the microbiome and health with evidence that microbiomes are affected by age, gender, diet, culture, geography and various physiological/pathological states (Albenberg & Wu, 2014;D'Argenio et al, 2013;Flint, 2012;Holscher et al, 2015;Olszewska & Jagusztyn-Krynicka, 2012). Therefore, it is no surprise that the field of IVD models of the human colon are also a vibrant field, as reviewed by others (Payne et al, 2012).…”

Section: Large Intestinal Phasementioning

“…The colon is increasingly recognized for its milieu of bacteria, fungi, protozoa and archaea and rich metabolic activity equated to that of the human liver (Nardone & Malfertheiner, 2011;O'Hara & Shanahan, 2006;Olszewska & Jagusztyn-Krynicka, 2012;Turnbaugh et al, 2007). Recent studies of the human colon microbiome have established various links between nutrition, the microbiome and health with evidence that microbiomes are affected by age, gender, diet, culture, geography and various physiological/pathological states (Albenberg & Wu, 2014;D'Argenio et al, 2013;Flint, 2012;Holscher et al, 2015;Olszewska & Jagusztyn-Krynicka, 2012). Therefore, it is no surprise that the field of IVD models of the human colon are also a vibrant field, as reviewed by others (Payne et al, 2012).…”

Section: Large Intestinal Phasementioning

“…14,15 The consumption of various nutrients affects the structure of the microbial community and provides substrates for microbial metabolism. 16 The microbiota can produce molecules absorbed by the host and can affect many important physiological processes. 16,17 Functional studies in animal models, as well as descriptive association studies in humans, provide evidence for the role of diet in disease pathogenesis through its effects on intestinal microbes.…”

Section: Introductionmentioning

“…16 The microbiota can produce molecules absorbed by the host and can affect many important physiological processes. 16,17 Functional studies in animal models, as well as descriptive association studies in humans, provide evidence for the role of diet in disease pathogenesis through its effects on intestinal microbes. 16 Couples who live together share their lifestyles.…”

Section: Introductionmentioning

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“…Specific changes in the microbiota were described in a wide range of diseases from inflammatory bowel disease (IBD) to atherosclerosis and cancer (1)(2)(3)(4).…”

Section: Introductionmentioning