Innate Immune System and Inflammation in Alzheimer's Disease: From Pathogenesis to Treatment (original) (raw)

“…Astrocytes and microglia activate the neuronal immune system in response to pathogens such as infection and vascular pathology [125],[126]. Several studies showed that senile plaques in the brains of patients with AD and of AD transgenic mice models were surrounded by an increased number of activated microglia [127].…”

Section: Reviewmentioning

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“…Astrocytes and microglia activate the neuronal immune system in response to pathogens such as infection and vascular pathology [125],[126]. Several studies showed that senile plaques in the brains of patients with AD and of AD transgenic mice models were surrounded by an increased number of activated microglia [127].…”

Section: Reviewmentioning

“…Several studies showed that senile plaques in the brains of patients with AD and of AD transgenic mice models were surrounded by an increased number of activated microglia [127]. Amyloid β also activates the neuronal immune system, and might cause a chronic inflammatory reaction that has a toxic effect on nerve cells [126]. Moreover, recent genetic studies have uncovered various genes for inflammation and immune response that seem to be associated with AD [128].…”

Section: Reviewmentioning

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“…There are various data on intravascular infiltration of periodontal disease-related bacteria and its spread to target organs thus far, but its mechanism of affecting diseases is not fully understood. On the other hand, the inflammatory response has been known to play a large role in the progression of cerebrovascular disorder and dementia, conditions that often occur in the elderly [8][9][10]; however, the effect of periodontal disease is not fully understood.…”

Section: Introductionmentioning

“…Developing novel strategies to protect cognition in the elderly population is critical for managing the disease burden and cost of care1. The pathogenesis and progression of Alzheimer’s disease (AD) (the first cause of dementia) are associated with various inflammatory processes23. Indeed, inflammatory processes play at least some role in the pathology of AD and mild cognitive impairment (MCI)4, which represents an intermediate state between normal cognitive aging and dementia.…”

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