Atomic basis of CRM1-cargo recognition, release and inhibition (original) (raw)

“…2 chromosome region maintenance 1 (CRM1), exportin 1, or XPO1, is uniquely required for the export of .200 different proteins to the cytoplasm, including nucleophosmin, survivin, p27, APC, BRCA1, and p53. 3 The effects of shuttled proteins often depend on their location; for example, in the nucleus, survivin helps attach centromeres to mitotic spindles, whereas in the cytoplasm, it interacts with caspases to inhibit apoptosis. 4 These proteins are prominent targets of oncogenic mutations, as are the components of the nuclear transport system that modulate their effects.…”