Synaptic basis of social dysfunction: a focus on postsynaptic proteins linking group‐I mGluRs with AMPARs and NMDARs (original) (raw)

“…Increases [Huber, Gallagher, Warren, & Bear, ] and decreases [Bateup, Takasaki, Saulnier, Denefrio, & Sabatini, ] in LTD induced by application of Group 1 mGluR agonists have been identified in genetic models of autism. Furthermore, Group I mGluRs, as well as AMPARs and NMDARs, are being targeted for their therapeutic potential in ASD [Connor, Bariselli, & Bellone, ]. To determine whether Group I mGluR function is altered in Shank3 E13 mutants 100 μM DHPG was bath applied for 10 min and LTD was determined as the average fEPSP at 55–60 min following the start of DHPG washout, normalized to the average baseline fEPSP (Fig.…”