Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies (original) (raw)

“…Since the data discussed above [10][11][12][13] indicates that, contrary to popular belief, there is an important risk of progression with NAFL to more serious fibrotic liver disease over time, we suggest it is now an appropriate time to consider changing the focus of the primary endpoint used in therapeutic trials for NAFLD, be it pharmacologic, life-style 14 or surgical 15 . The aim of the primary care physician and the metabolic clinician at least, needs to focus on prevention or reversal of early disease.…”