Caecal pH is a biomarker of excessive colonic fermentation (original) (raw)

“…It must be noted though that heightened right colonic fermentation has been shown to be a potential pathophysiological factor in irritable bowel syndrome (Farmer et al . ; Ringel‐Kulka et al . ).…”

Section: Discussionmentioning

“…The pH drop at the ileocaecal junction is attributed to the production of short‐chain fatty acids by bacterial fermentation . It was shown recently that the pH drop between ileum and caecum is variable between subjects and in addition, depends on diet . Therefore, the pH drop upon ileocaecal valve passage was less pronounced in some subjects.…”

Section: Discussionmentioning

“…short-chain fatty acids) through bacterial fermentation. [52][53][54] In the event that the ICJ cannot be identified, SBTT + CTT can be used as a surrogate to diagnose delayed transit. 33 Abnormalities in intra-luminal pH may feasibly represent alterations in gut microbiota.…”

Section: Discussionmentioning