Differential roles of microglia and monocytes in the inflamed central nervous system (original) (raw)

“…p21 is a p53 target gene, implicated in cell cycle arrest, tumor suppression and used as a marker of cellular senescence (Serrano et al ., 1997). Interestingly, genes previously reported in activated microglia such as Egr‐1, CCl3, Chi3l3, Chi3l4, and Lyz1 (McMahon & Monroe, 1996; Chang et al ., 2001; Babcock et al ., 2003; Friedle et al ., 2011) and in proliferation such as Fos, Jun, and Mapk8 (Yamasaki et al ., 2014) were found to be mildly but significantly downregulated in G4 mTerc −/− microglia.…”