6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27 (original) (raw)

“…Cell proliferation is strongly dependent upon hypoxia and glycolysis because there is the molecular connection between cell cycle progression and the provision of substrates essential for this purpose [30,33]. The endoplasmic reticulum has an important position as a signal integrator in both normal and malignant cells because the endoplasmic reticulum stress signaling pathways have connections with other plasma membrane receptor signaling networks and with numerous metabolic pathways [19,30].…”

Section: Fig 4 Effect Of Hypoxia On the Expression Of Insulinlike Gmentioning

“…Aerobic glycolysis is the primary metabolic pathway utilized by cancer cells. Glycolytic enzymes are always greatly increased and/or deregulated in cancer cells [8,9,12,19,35]. Indeed, their abnormal expression is commonly observed in various types of cancers.…”

Section: Discussionmentioning

“…Once activated, p38 proteins translocate from the cytosol to the nucleus causing cellular responses through the phosphorylation of its downstream transcription factors. Our liposomal formulation have shown to reduce the expression of Cdk2 which is critical during the G1 to S phase transition (44). Moreover, reduction in expression of Bcl-2 and survivin are also involved in apoptosis induction in lung cancer cells.…”

Section: Discussionmentioning