A single-stranded architecture for cotranscriptional folding of RNA nanostructures (original) (raw)

“…However, the complexity of an individual origami limits the scalability of its size relative to tile-based systems, which can assemble several microns in length. [45,32,89] 2D patterns [5] 3D patterns [12,38,43] Filaments, lattices [58,68,82] Rings, cubes, prisms, tubes [57,69,85] Lattices [78] Rings, cubes [77] Applications Algorithmic assembly [4,27,90] Functionalization with ligands [28,93] Scaffolding [91,92] Biomimetic assays [94] Drug delivery [56,60,61] Spatial organization of proteins [3,81] Recent work has tried to address this limitation with the development of origami tiling or connector systems. Individual origami tiles or blocks can be interfaced in two ways: the first approach is the use of sticky ends [39,40,41], where binding patterns are assigned by Watson-Crick base pairing.…”