Expression ofZNF804Ain Human Brain and Alterations in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder (original) (raw)

“…However, we were unable to investigate this possibility in terms of the abundance of the encoded mGlu3Δ4 variant, because the new antibody generated against this sequence proved unsuccessful, failing to detect the variant in human brain tissue but instead detecting a smaller and non-specific band. Other possible mechanisms of genetic association include modulation of an antisense GRM3 transcript (Buonaguro et al, 2015), or effects of genotype on mGlu3 which are limited to specific locations or developmental stages, as is the case for some other schizophrenia risk genes (Kleinman et al, 2011, Birnbaum et al, 2014, Paterson et al, 2014, Tao et al, 2014). …”