A novel mutation in FOXN1 resulting in SCID: A case report and literature review (original) (raw)

“…T cells had a poor or absent proliferative response to mitogens and exhibited an oligoclonal TCR repertoire [2][3][4]. NK and B cells, although normal in number, were also functionally impaired with abnormal specific antibody production [2][3][4][5].…”

Section: Focus On Immunodeficiency: Foxn1 In Tecs and T Cell Developmentmentioning

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“…T cells had a poor or absent proliferative response to mitogens and exhibited an oligoclonal TCR repertoire [2][3][4]. NK and B cells, although normal in number, were also functionally impaired with abnormal specific antibody production [2][3][4][5].…”

Section: Focus On Immunodeficiency: Foxn1 In Tecs and T Cell Developmentmentioning

“…+ recent thymic emigrants [4], and naïve CD4 + CD45RA + T cells, the latter turning in favor of a CD45RO + memory phenotype [3,4,22]. The identification of the nude/SCID phenotype greatly contributed to unravel important issues of thymic and T cell development.…”

Section: Focus On Immunodeficiency: Foxn1 In Tecs and T Cell Developmentmentioning

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