Over-expression of the Sirt3 sirtuin Protects neuronally differentiated PC12 Cells from degeneration induced by oxidative stress and trophic withdrawal (original) (raw)

“…10, A and B). In light of the oxidative stress-ameliorative effects assigned to SIRT3 function in caloric restriction studies and the protective effect of overexpressed SIRT3 in neural cells (41,42), stimulation of SIRT3 activity has been proposed to reduce mitochondrial deficits associated with cerebral oxidative stress and neurodegeneration (76). However, our studies showing that Sirt3 gene ablation protected mitochondria against cerebral IR-induced damage suggest that small molecule inhibitors of SIRT3 activity could be beneficial in the stroke treatment.…”

Section: Discussioncontrasting

“…Thus, SIRT3 has been shown to operate in both stress resistance (anti-apoptosis) (37,38) and tumor suppression (pro-apoptosis) (39,40). In neuronal cells, SIRT3 overexpression protected cultured cortical neurons against excitotoxicity (41) and differentiated PC12 cells from oxidative stress-induced cell death (42).…”

Section: Increases Enzyme Activity Investigation Of the Sirt3 Role Imentioning