Aerosol Azacytidine Inhibits Orthotopic Lung Cancers in Mice through Its DNA Demethylation and Gene Reactivation Effects (original) (raw)

“…The aerosol equipment and the administration method were the same as described previously 10 . Briefly, the aerosol was generated with PARI’s personal compressor and LC Star nebulizer.…”

Section: Methodsmentioning

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“…The aerosol equipment and the administration method were the same as described previously 10 . Briefly, the aerosol was generated with PARI’s personal compressor and LC Star nebulizer.…”

Section: Methodsmentioning

“…The nose-only exposure system (CH Technologies, Inc.) linked with PARI’s aerosol system in a closed chemical hood was used for aerosol administration to mice (Figure 1c), and the aerosol time was strictly controlled. All aerosol doses used in the experiments reported in this paper are “lung deposited doses” calculated as previously reported by our group 10 .…”

Section: Methodsmentioning

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“…Lung cancer is a common and very serious type of cancer, is one of the major causes of cancer related mortality worldwide (1), and >80% of lung cancer cases are non-small cell lung cancer (NSCLC) (2). Although there have been improvements in diagnostic approaches and the introduction of novel therapeutic agents during the last decades, the 5-year survival rate of lung cancers remains low due to high recurrence rates and early metastasis (3).…”

Section: Introductionmentioning