A dose-response study of consuming high-fructose corn syrup–sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults (original) (raw)

“…Complexity, cost, compliance, and potential ethical issues likely prohibit the conducting of such studies. Nevertheless, some short-term interventional studies, even those within the range of "normal" fructose consumption, show that fructose can rapidly impair intermediate physiological endpoints like circulating lipids and insulin sensitivity in humans (25). Several recent reviews comprehensively discuss the physiological effects of added fructose or sugar on pathophysiological endpoints in human subjects (26,27).…”

Section: Intermediary Fructose Metabolismmentioning

“…La fosforilación de la fructosa catalizada por la fructoquinasa a fructosa 1-fosfato, (resultado de la conversión de ATP a AMP y a una disminución del fosfato inorgá-nico), según Stanhope et al (2015) conduce a la producción de ácido úrico por la vía de la degradación de la purina. Así, altos niveles de ácido úrico estarían asociados a NAFLD, enfermedad cardiovascular y síndrome metabólico.…”

Section: Factores De La Dietaunclassified

“…(10)(11)(12)(13) Extensive reviews and metaanalyses have also been generated on the link between SSB consumption and weight gain and the bulk of these supports the direct association between SSB consumption and obesity, including the most recent meta-analysis. (14) SSB consumption can also, directly or indirectly, promote the onset of hypertension, (15)(16)(17)(18) dyslipidemia, (18,19) and impaired glucose tolerance (Figure 1). (20) Evidence from these studies suggests that the effects of SSB consumption occur partly through direct and indirect (increased calorie intake and weight gain) mechanisms (refer to Table I).…”

Section: Scientific Advisory Committee On Nutrition and Americanmentioning