Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells (original) (raw)

“…X-SCID is caused by mutations in the gene encoding the g common chain shared by several cytokine receptors, including the interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptors. In view of these receptors' roles in hematopoiesis, X-SCID is characterized by an early block in T and NK cell differentiation, the complete absence of T and NK cells and normal-to-elevated numbers of poorly functional, mature B cells [12,13].…”