Adipose Tissue-Residing Progenitors (Adipocyte Lineage Progenitors and Adipose-Derived Stem Cells (ADSC)) (original) (raw)

“…Emerging studies suggest multiple functional types of MAT exist (called constitutive and regulated MAT) that differs in timing of adipocyte appearance, lipid composition, genetic determinants and gene expression [119]. MAT is Myf5-Cre negative and Vav1-Cre negative , which labels hematopoietic stem cells [120]. Moreover, only about half of the marrow adipocytes are marked with PDGFRα-Cre in contrast to all other adipocyte pools that have been examined using this Cre [48, 120].…”

Section: Discussionmentioning

“…MAT is Myf5-Cre negative and Vav1-Cre negative , which labels hematopoietic stem cells [120]. Moreover, only about half of the marrow adipocytes are marked with PDGFRα-Cre in contrast to all other adipocyte pools that have been examined using this Cre [48, 120]. Marrow adipocytes but no others are labeled with Osx1-Cre (Osx1 is a transcription factor essential for osteoblast differentiation) supporting their emergence from an embryonic precursor pool shared with bone [120, 121].…”

Section: Discussionmentioning

“…“Off-target” effects of pharmacologic HO-1 inducers (discussed in ref. 24), and the use of bone marrow- as opposed to adipose tissue derived mesenchymal stem cells in these studies may explain the discrepancies, considering the cell-autonomous differences between WAT- and bone marrow derived ‘preadipocytes’6364. Mechanistically, HO-1 acts upstream of Cebpα and PPARγ, as overexpression of HO-1 in 3T3-L1 cells which require MCE to trigger the terminal differentiation transcription cascade, blocks their differentiation only when overexpressed before MCE occurs (Fig.…”

Section: Discussionmentioning

“…Marrow adipocytes are a developmentally distinct white adipocyte population. MAT, but not other WAT depots, is derived from cells once expressing Osx1 (Berry et al 2015). MAT expansion occurs in response to various pharmacological or physiological triggers, such as glucocorticoids, anti-diabetic thiazolidinediones, estrogen deficiency, obesity, and aging.…”

Section: Maintenance and Expansion Of Wat In Adultsmentioning