Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1 (original) (raw)

“…Recently, our studies further indicated that the ALDH2 mutation is tied with levels of high-sensitivity C-reactive protein, a classical inflammatory biomarker, and the number of circulating endothelial progenitor cells [15]. In addition, previous studies showed that overexpression of ALDH2 attenuates myocardial apoptosis [16] and ALDH2 plays an important role in myocardial protection [17–19]. It is well conceived that lipids, endothelial dysfunction or injury-repair imbalance, and inflammation play critical roles in atherosclerosis progression and atherosclerotic plaque vulnerability, which are recognized as a pivotal mechanism of ACS [20].…”