Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury (original) (raw)

“…In addition to the previously highlighted transcription factors, several others — namely Myc proto-oncogene protein (MYC) 137 , hypoxia-inducible factor 1α (HIF1α) 138 , CREB1 (REFS 36,113 ), SOX11 (REFS 139–143 ), TP53 (REFS 46,144 ), SRF48,145 and XBP1 (REFS 90,91 ) — have been identified to have roles in axon regeneration (see TABLE 1 and REFS 146,147 ). As little is known about the mechanisms by which these transcription factors are activated after injury, their regulation during development or their downstream targets, they will not be further discussed in detail here.…”