New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer (original) (raw)

“…The PI3K/AKT/GSK-3β pathway is a classical signalling pathway in tumourigenesis [36, 37], and its activation upregulates the expression of Snail and Slug, thereby promoting EMT [20, 38, 39] and inducing the transition from G1 to S phase [40, 41]. In this study , we found that the loss of ZNF703 expression decreased the expression of p-PI3K, p-Akt, and p-GSK-3β.…”