Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies (original) (raw)

“…Pharmacological therapies to treat tumors typically induce the death of cells that are rapidly proliferating or by blocking signal transduction pathways that directly increase tumor cell survival (Dominguez-Brauer et al, 2015; Pistritto et al, 2016). However, an alternative approach may be to block the production of pro-survival factors, such as IL-10.…”

Section: Introductionmentioning

“…Pharmacological therapies to treat tumors typically induce the death of cells that are rapidly proliferating or by blocking signal transduction pathways that directly increase tumor cell survival (Dominguez-Brauer et al, 2015; Pistritto et al, 2016). However, an alternative approach may be to block the production of pro-survival factors, such as IL-10.…”

Section: Introductionmentioning

“…Most current chemotherapeutic agents act through the activation of the apoptosis signal pathway [20]. Our hoechst 33258 staining and Annexin V-FITC/PI staining results indicated that lapachol could significantly induce the apoptosis of C6 cells in dose dependent manners (Fig.…”

Section: Discussionmentioning

“…Jest to możliwe dzięki wydzielaniu proapo-effectiveness of current therapies. This is possible due to the extrinsic induction of apoptosis by TRAIL signalling or inhibition of the antiapoptotic activity of Bcl-2 protein or IAP protein [43,44].…”

Section: Unikanie Apoptozymentioning

“…Szczegółowe poznanie ścieżek apoptotycznych i antyapoptotycznych oraz zrozumienie funkcji białek regulatorowych zaangażowanych w te szlaki pozwala na uwrażliwienie komórek nowotworowych na apoptozę, a tym samym poprawę skuteczności obecnych terapii. Możliwe jest to dzięki zewnątrzpochodnemu wywoła-niu apoptozy poprzez sygnalizację TRAIL lub zahamowanie antyapoptotycznej aktywności białka Bcl-2 lub białka IAP [43,44].…”

Section: The Ability To Invade and Form Metastasesunclassified