Esophageal adenocarcinoma and squamous cell carcinoma in children and adolescents: Report of 3 cases and comprehensive literature review (original) (raw)

“…Esophageal neoplasms in children are summarized in Table 1 (61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75). Caustic ingestion, tobacco use, and history of esophageal atresia repair are considered risk factors for both EAC and ESCC (61,62). Both EAC and ESCC, found near or at an anastomotic site, are seen as long-term sequela (>30 years) after reconstruction of esophageal atresia (76)(77)(78).…”

Section: Epidemiology and Clinical Presentationmentioning

“…GER and BE are considered risk factors for EAC (61,79). Approximately 60% of pediatric patients with EAC have pre-existing conditions associated with GER, such as hiatal hernia, esophageal atresia repair, and obesity (62). In a case series of fourteen pediatric patients with EAC, 78% of cases were associated with BE, suggesting that, similar to adults, BE is a strong risk factor for the development of EAC (61).…”

Section: Epidemiology and Clinical Presentationmentioning