FOXN1 recombinant protein enhances T‐cell regeneration after hematopoietic stem cell transplantation in mice (original) (raw)

“…Importantly, thymic expression of both Bmpr1a and Bmpr2 were identified on TEC populations, with a higher expression of the non-redundant Bmpr2 on cTECs ( 85 ); consistent with BMP4-induced expression of FOXN1 and its downstream target delta-like 4 (DLL4) specific to cTECs ( 85 , 87 ). Although the importance for FOXN1 and DLL4 for the development of TECs and thymocytes, respectively, has been well studied ( 88 , 89 ), recent findings have also highlighted their importance for thymic regeneration, with intrathymic concentration of DLL4 profoundly impacting on thymic size ( 90 ), and reports suggesting that the induction of FOXN1 can counteract age-associated thymic involution ( 91 ), acute damage ( 85 ), and thymic damage post-transplantation ( 92 ). While much of the role of BMP4 seems to be mediated by induction of the FOXN1/DLL4 axis, given the requirement for BMP4 in in vitro differentiation of TECs from multipotent progenitors ( 93 – 95 ), it is possible that an alternate mechanism may be by stimulating bipotent progenitors present in the adult thymus ( 96 – 99 ).…”

Section: Strategies Of Boosting Thymic Function I: Targeting Non-hemamentioning