Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke (original) (raw)

“…Selective ablation of proliferating microglia after focal ischemia in a transgenic mouse also demonstrated exacerbation of stroke injury with an altered inflammatory response [64]. A similar beneficial effect of microglia in stroke was reported in a study where there was a 60 % increase in infarct size by selective elimination of microglia, which the effect was reversed by repopulating the cells [65]. In contrast, microglia ablation was either protective or had no effect in models of other neurodegenerative diseases, including Alzheimer's disease [66], amyotrophic lateral sclerosis [67], and experimental autoimmune encephalomyelitis [68].…”

Section: Microgliamentioning

“…Selective ablation of proliferating microglia after focal ischemia in a transgenic mouse also demonstrated exacerbation of stroke injury with an altered inflammatory response [64]. A similar beneficial effect of microglia in stroke was reported in a study where there was a 60 % increase in infarct size by selective elimination of microglia, which the effect was reversed by repopulating the cells [65]. In contrast, microglia ablation was either protective or had no effect in models of other neurodegenerative diseases, including Alzheimer's disease [66], amyotrophic lateral sclerosis [67], and experimental autoimmune encephalomyelitis [68].…”

Section: Microgliamentioning

“…Microglia are an important inflammatory cell in the neocortex (Dheen et al, 2007) and have been shown to rapidly respond to brain injury (Davalos et al, 2005; Szalay et al, 2016). Therefore, we sought to determine whether there was a change in microglial density following both forms of TBI as well as whether there was a relationship between microglial density and serotonin axon loss.…”

Section: Resultsmentioning

“…Brain ischemia activates microglia that can damage neural structure or facilitate neural repair, depending on timing and context (52)(53)(54)(55). Microglia express IL-15 receptors and thus could be receptive to astrocytic IL-15.…”

Section: Discussionmentioning