Specification of tissue-resident macrophages during organogenesis (original) (raw)

“…In the steady state, they arise from two distinct sources: first, continuously recruited from circulating monocytes in the gut [10], the dermis [11] and the heart [12], and second, from fetal monocytes and yolk sac precursors that colonize the whole embryo between E8.5 and E10.5, becoming self-renewal differentiated tissue-resident macrophages [13,14,15 ]. Similar to other systems such as mammalian forebrain, heart and liver [16] as well as cells that arise from hematopoiesis [17 ], macrophage development involves substantial reorganization of the chromatin landscape [6 ,7 ].…”

Section: The Temporal and Spatial Properties Of Macrophage Regulatorymentioning