Frailty Index Predicts All-Cause Mortality for Middle-Aged and Older Taiwanese: Implications for Active-Aging Programs (original) (raw)
“…Population aging is a global problem, imposing substantial and rapidly increasing health care and socio‐economic burdens . Its most exigent manifestation is frailty, a distinct geriatric phenotype prognostic of disability, loss of independence, and earlier death, irrespective of age or morbidity status . Frail individuals are less likely and slower to recover from injury or stressful life events, steepening the trajectory of physical, functional, and cognitive decline .…”
Section: Introductionmentioning
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“…Population aging is a global problem, imposing substantial and rapidly increasing health care and socio‐economic burdens . Its most exigent manifestation is frailty, a distinct geriatric phenotype prognostic of disability, loss of independence, and earlier death, irrespective of age or morbidity status . Frail individuals are less likely and slower to recover from injury or stressful life events, steepening the trajectory of physical, functional, and cognitive decline .…”
Section: Introductionmentioning
“…The nexus of ‘phenotypic’ frailty involves loss of muscle strength and mass, impaired locomotion, diminishing physical function, and fatigue . Though complex, there is strong evidence that these factors are modifiable, making them salient targets for preventing or postponing the adverse consequences of frailty . However, devising pragmatic and demonstrably effective interventions for this multifaceted condition has proven challenging .…”
Section: Introductionmentioning
“…Another study in Taiwan had same limitations mentioned above. [ 18 ] To the best of our knowledge, this is the first study to construct a frailty index using a nationwide health insurance claims database. We described the characteristics of the mFI and demonstrated its ability to predict all-cause mortality and hospitalization over an extended time period (up to 8 years).…”
Section: Discussionmentioning
“…However, most risk score systems for predicting overall mortality have been developed to focus in Western general population [ 9 – 17 ], and few studies in non-Western general population [ 18 – 21 ]. Three works explored the 5-year mortality risk by focusing on middle-aged or elderly adults residing in a community in Taiwan [ 18 – 20 ]. Two of these studies considered frailty markers [ 19 , 20 ], and one considered cardiovascular/metabolic, inflammatory, and neuroendocrine markers [ 18 ].…”
Section: Introductionmentioning
“…Three works explored the 5-year mortality risk by focusing on middle-aged or elderly adults residing in a community in Taiwan [ 18 – 20 ]. Two of these studies considered frailty markers [ 19 , 20 ], and one considered cardiovascular/metabolic, inflammatory, and neuroendocrine markers [ 18 ]. None of them considered arterial stiffness, developed a prediction model for expanded cardiovascular mortality, and/or adopted the derived risk-score system.…”
Section: Introductionmentioning