Stress-specific differences in assembly and composition of stress granules and related foci (original) (raw)

“…In addition, some proteins which localize to stress granules contain intrinsically disordered regions (IDR) which could promote physical protein-protein interactions and contribute to stress granule assembly [5,7,8,9,10,11,13]. Stress granules are comprised of a dense network of physical interactions and stress granule composition can change in response to different stressors [1,4,6]. Therefore, a broader understanding of stress granule composition is likely provide insights into RNP granule formation and RNA regulation.…”

Section: Description Of Theoretical Basis and Framework For The Tementioning