Depletion of Mitofusin-2 Causes Mitochondrial Damage in Cisplatin-Induced Neuropathy (original) (raw)

“…Mitochondrial dysfunction is commonly observed in CIPN (Figure 1 ). Abnormal mitochondrial morphology including swelling, vacuolation, enlargement, and loss of cristae structure have been observed in peripheral nerve axons (Flatters and Bennett, 2006 ; Xiao et al, 2012 ; Zheng et al, 2012 ; Bobylev et al, 2017 ), but not in the surrounding Schwann cells (Xiao et al, 2012 ) in several CIPN animal models. Potential causes of altered mitochondria include paclitaxel-induced depletion of mRNAs encoding mitochondrial fission/fusion machinery in distal axons (Bobylev et al, 2015 ).…”

Section: Pathology Of Cipnmentioning

“…Potential causes of altered mitochondria include paclitaxel-induced depletion of mRNAs encoding mitochondrial fission/fusion machinery in distal axons (Bobylev et al, 2015 ). Mitochondria dynamics may be altered in cisplatin-treated animals due to decreased level of mitochondrial fusion protein MFN2 in distal axon segments (Bobylev et al, 2017 ). Moreover, increased mitochondrial fragmentation, as well as decreased mitochondrial fission/fusion dynamics and motility, occur rapidly in vincristine-treated DRG cultures and precede axon degeneration (Berbusse et al, 2016 ).…”

Section: Pathology Of Cipnmentioning