Integrated genomic and molecular characterization of cervical cancer (original) (raw)

“…The Cancer Genome Atlas (TCGA) data on cervical cancer are also available [75]. A comparison of the genomic landscape of HPV-associated HNSCCs with that of cervical carcinoma reveals a similar profile, characterized by recurrent integrations in RAD51B , NR4A2 , and TP63 , which result in aberrant forms of these proteins in both HPV-positive HNSCC and HPV-positive cervical cancer.…”

Section: Whole Genome Landscape Hnscc and Hpvmentioning

“…Temporality: HR-HPVs infections precede pre-cancerous cervical lesions and cervical cancer by years to decades. Biological gradient: Unclear, but early studies show that cervical cancer is associated with high viral loads [10-12]. Biological plausibility: HR-HPVs are powerful carcinogens that immortalizes human keratinocytes in vitro .…”

Section: Hr-hpv and Cervical Cancermentioning

“…Analogy: Other DNA viruses can induce cancers in humans, and species-specific papilloma viruses can induce cancers in animals.Although early cervical cancer can be treated with surgery or radiation, metastatic cervical cancer is incurable and new therapeutic approaches are urgently needed. While most HPV infections are cleared within months, some infection persist and viral oncogenes constantly express to inactivate p53 and Rb, leading to increased genomic instability, accumulation of somatic mutations, and in some cases integration of HPV into the host genome [10, 11]. …”

Section: Hr-hpv and Cervical Cancermentioning

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“…10 In women, cervical cancer has been linked to HPV, with only a small fraction being HPV-negative. 11 More than 40,000 of these cases occurred in men. 12 Furthermore, in the future, males are predicted to have a greatly increasing incidence of anal, penile and oropharyngeal cancers.…”

mentioning