Moonlighting Motors: Kinesin, Dynein, and Cell Polarity (original) (raw)

“…Moreover, kinesin and dynein are the main motor proteins that traffic intracellular cargo along microtubules, including vesicles, organelles, protein complexes, and mRNA. 31 Previous studies revealed that disassembling microtubules leads to dysfunction in kinesin-and dynein-driven axonal transport with central nervous system injury or neurodegenerative diseases, and this compromised axonal transport is closely associated with early neurological dysfunction in ICH. 32 Similarly, we found that expression of kinesin and dynein was significantly decreased following disruption of microtubules in damaged dopamine neurons; this indicates that axonal transport in the nigrostriatal pathway was damaged.…”

Section: Discussionmentioning

“…Moreover, kinesin and dynein are the main motor proteins that traffic intracellular cargo along microtubules, including vesicles, organelles, protein complexes, and mRNA. 31 Previous studies revealed that disassembling microtubules leads to dysfunction in kinesin-and dynein-driven axonal transport with central nervous system injury or neurodegenerative diseases, and this compromised axonal transport is closely associated with early neurological dysfunction in ICH. 32 Similarly, we found that expression of kinesin and dynein was significantly decreased following disruption of microtubules in damaged dopamine neurons; this indicates that axonal transport in the nigrostriatal pathway was damaged.…”

Section: Discussionmentioning

“…1b [8,9]. Parallel array of MTs, acting as reinforcing components with a main function of transporting electrochemical cargo, are the stiffest structural element within the axon [10][11][12][13].…”

Section: Introductionmentioning

“…Kinesins constitute a superfamily of microtubule-based molecular motor enzymes that couple the chemical energy from ATP turnover to force production for diverse cellular functions (reviewed in (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)). Kinesins are classified into 15 different subfamilies, yet they share a structurally conserved kinesin motor domain (1,3,(13)(14)(15)(16).…”

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