Tiron ameliorates high glucose‐induced cardiac myocyte apoptosis by PKCδ‐dependent inhibition of osteopontin (original) (raw)

“…In support, these changes were recently attributed to upregulation of reactive oxygen species (ROS) [30] . Furthermore, another group [31] added and confirmed by proving that using a potent antioxidant as tiron could interfere with ROS pathway and hence prevents apoptosis-related cardiovascular diseases including diabetic cardiomyopathy.…”

Section: Discussionmentioning

“…In support, these changes were recently attributed to upregulation of reactive oxygen species (ROS) [30] . Furthermore, another group [31] added and confirmed by proving that using a potent antioxidant as tiron could interfere with ROS pathway and hence prevents apoptosis-related cardiovascular diseases including diabetic cardiomyopathy.…”

Section: Discussionmentioning

“…Hyperglycemia is a hallmark feature of both type 1 and type 2 diabetes. Previous study has evidenced that high levels of glucose induce oxidative stress and cell apoptosis in cardiomyocytes [30,42], which can be protected by adiponectin administration [43]. Using this model, we wanted to further confirm the role of HSP60 in mediating adiponectin signaling.…”

Section: Hsp60 Knockdown Mitigated the Protective Effects Of Adiponecmentioning

“…High glucose treatment was performed as our described previously [29,30]. The control group received the treatment of 5.5 mM glucose and the identical concentration of mannitol which act as osmotic control to remove a hyperosmolar effect.…”

Section: Cell Culture and Treatmentmentioning

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