Nicotinic modulation of descending pain control circuitry (original) (raw)

“…Excitability of layer 4/5 pyramidal neurons in the PL increases in complete Freund’s adjuvant (CFA)-induced inflammatory mice (Wu et al, 2016 ), and bilateral lesions of the PL attenuate CFA-induced heat hyperalgesia (Wang et al, 2015 ). PL may regulate pain through its projections to a number of other brain areas (Kucyi et al, 2013 ; Khan et al, 2014 ; Yu et al, 2014 ; Lee et al, 2015 ; Vachon-Presseau et al, 2016 ), including amygdala, nucleus accumbens (NAc), hippocampus and in particular periaqueductal gray (PAG), a critical component of the descending pain modulatory system (Umana et al, 2017 ).…”