Prognostic Impact of Diabetes on Long-term Survival Outcomes in Patients With Heart Failure: A Meta-analysis (original) (raw)

“…A recent meta‐analysis of 31 registries and 12 clinical trials with 381 725 patients with acute and chronic HF, with a median follow‐up of 3 years confirms that T2DM is independently associated with a higher risk of all‐cause death (random‐effects HR 1.28), CV death (HR 1.34), hospitalization (HR 1.35), and the combined endpoint of all‐cause death or hospitalization (HR 1.41), and the observed long‐term risk appears greater in patients with chronic than in those with acute HF …”

Section: Type 2 Diabetes Mellitus Clinical Status and Outcomes In Pamentioning

“…A recent metaanalysis, including 31 registries and 12 clinical trials (combining studies of both acute and chronic heart failure), concluded that diabetes mellitus is independently associated with a higher risk of all-cause death (HR 1.28; 95% CI, 1.21-1.35). 73 Diabetes likely has deleterious effects in all forms of heart failure, including HFrEF and HFpEF, and both ischemic and nonischemic cardiomyopathy. Therefore, it is important to identify and treat risk factors for diabetes early to avoid the morbidity and mortality associated with diabetes and associated conditions, especially heart failure.…”

Section: S8mentioning

“…Such uncertainty has led to the proliferation of new risk scores appearing in the literature in the last years, with mixed results [41][42][43][44][45][46][47]. As a partial solution to improve models' effectiveness, recent published studies included cohorts restricted to specific classes of patients (for example, elderly or diabetic) [48,49]. These attempts have led to tailored models and risk scores [50,51] with better but still not optimal performance.…”

Section: Introductionmentioning