Adipose tissue and reproductive health (original) (raw)
“…Moreover, adiponectin can affect the HPG axis due to the expression of adiponectin receptors in the hypothalamus, pituitary gland, and gonads . In detail, adiponectin is a regulator of puberty onset as it inhibits the secretion of kisspeptin and GnRH in the hypothalamus and the release of GH and LH in the pituitary gland, and thereby inhibiting the onset of puberty (Figure ) . Individuals with obesity often have low levels of adiponectin .…”
Section: The Onset Of Puberty In Girlsmentioning
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“…Moreover, adiponectin can affect the HPG axis due to the expression of adiponectin receptors in the hypothalamus, pituitary gland, and gonads . In detail, adiponectin is a regulator of puberty onset as it inhibits the secretion of kisspeptin and GnRH in the hypothalamus and the release of GH and LH in the pituitary gland, and thereby inhibiting the onset of puberty (Figure ) . Individuals with obesity often have low levels of adiponectin .…”
Section: The Onset Of Puberty In Girlsmentioning
“…The expression of these adipokines in the ovaries suggests a role within the reproductive system; however, the exact biological processes have to be examined. Thus, specifically leptin, adiponectin, and inflammatory cytokines produced by WAT could be permissive key players during an early onset of puberty in girls with obesity . As an exception, HMW adiponectin seems to have a stimulatory effect on peripheral reproductive function as HMW is not able to cross the blood brain barrier …”
Section: The Onset Of Puberty In Girlsmentioning
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“…15 Abnormal fat deposition, nutrient balance, oxidative stress, and energy state have also been associated with higher rates of implantation failure and defective implantation leading to adverse consequences for pregnancy. 16,17…”
Section: Implantationmentioning
“…As the interface between the invasive trophoblasts and maternal spiral arterioles is responsible for placental perfusion, inadequate microvascular remodeling, perfusion, and/or reactivity have been associated with reduced placental blood flow and reproductive disorders, such as IUGR and preeclampsia . Abnormal fat deposition, nutrient balance, oxidative stress, and energy state have also been associated with higher rates of implantation failure and defective implantation leading to adverse consequences for pregnancy …”
Section: Introductionmentioning