Raspberry differentially improves age-related declines in psychomotor function dependent on baseline motor ability (original) (raw)

“…One reason for the lesser effect on errors may be that rats generally do not commit a large number of working or reference memory errors, so there is not much room to reduce these numbers (floor effect). The results of this study are somewhat in contrast to those seen in one of our previous studies, which showed that raspberry supplementation did enhance motor performance in poor performers, but did not preserve motor performance among good performers (19). It could be that the decline in psychomotor ability between 17 and 20 months of age in F344 rats is more difficult to protect against than the decline in cognition during this same period, or it could be that BB better preserves function compared to raspberry.…”

Section: Discussioncontrasting

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“…One reason for the lesser effect on errors may be that rats generally do not commit a large number of working or reference memory errors, so there is not much room to reduce these numbers (floor effect). The results of this study are somewhat in contrast to those seen in one of our previous studies, which showed that raspberry supplementation did enhance motor performance in poor performers, but did not preserve motor performance among good performers (19). It could be that the decline in psychomotor ability between 17 and 20 months of age in F344 rats is more difficult to protect against than the decline in cognition during this same period, or it could be that BB better preserves function compared to raspberry.…”

Section: Discussioncontrasting

“…We found that poor performers showed the greatest improvement in motor function when fed for 8 weeks with 1%-2% raspberry supplemented in the diet, whereas average and good performers were not as likely to benefit from raspberry supplementation. In addition, although pre-diet levels of circulating pro-inflammatory cytokines were not predictive of motor performance in this study, higher levels of interleukin-1β were correlated with reduced motor performance post-diet (19).…”

contrasting

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