Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using 13C-Labeling and QTOF-MS (original) (raw)

“…As reviewed above, Moran found a higher turnover rate of absorbed all-trans lycopene compared to cislycopene, suggesting that there may be differential degradation or metabolism of the different isomers within body tissues and that trans-to-cis isomerization may occur. Further analyses of serum samples from Moran et al were performed by Cichon et al and a 1,2 lycopene epoxide was found in plasma beginning 2-4 h post-dosing and represented 1.7% of the dose [97]. This work supports previous work by Khachik et al, who enrolled three lactating women one month postpartum and analyzed breastmilk and serum for carotenoids [98].…”

Section: Excretionsupporting

“…Isotopically labeled carotenoids are an effective way of investigating lycopene excretion in vivo. Such studies have been carried out using lycopene with rats, gerbils, and humans [92,[95][96][97]. One study used F344 male rats that were fed an AIN-93G diet enriched with lycopene (25 mg per kg diet) [95].…”

Section: Excretionmentioning

“…Its expression by human intestinal cells further supports the hypothesis that it may act during digestion . Indeed, LYC metabolites have been found circulating in human plasma, although the origin of these metabolites has not been established.…”

Section: Introductionsupporting

“…Also, this study was conducted in healthy male subjects, and differences could be observed in other demographic groups. Finally, only apo‐lycopenoids (i.e., <40 carbon metabolites) were studied in this work, to the exclusion of other reported LYC epoxides and diols, which have been previously examined …”

Section: Discussionmentioning

“…Some studies suggest that metabolites of lycopene may play a role in the biological activities of lycopene. However, only a limited number of studies have investigated the role of lycopene metabolites in vivo [ 128 , 129 , 130 , 131 , 132 ].…”

Section: Carotenoid Lycopene: Chemistry and Its Isomersmentioning